Parker is a central character in the MCU's ' Infinity Saga', appearing in six MCU films as of 2022. To distinguish himself from the other versions, he is referred to by the other Parkers as ' Peter-One'. Holland's version of the character is the successor to the Peter Parker played by Tobey Maguire in Sam Raimi's Spider-Man trilogy (2002–2007) and the Peter Parker played by Andrew Garfield in Marc Webb's The Amazing Spider-Man duology (2012–2014), both of whom reprise their roles and appear in Spider-Man: No Way Home (2021) as supporting characters to Holland's Parker. Strange's spell causes the multiverse to fracture, bringing in two alternate versions of Peter and the villains they battled, but it is eventually resolved by casting a new spell that permanently erases the world's shared knowledge of his civilian persona, including his relationships with his loved ones, friends, and other superhero allies.

Following the Blip, Parker briefly encounters and fights the manipulative Mysterio while on a school trip across Europe Mysterio frames Parker for his murder and reveals his identity to the world, prompting Parker to seek Stephen Strange's help months later to reverse this. Parker is eventually recruited by Tony Stark, who mentors him and recruits him into the Avengers during the battle against Thanos. Parker is initially depicted as a student at the Midtown School of Science and Technology who later received spider-like and superhuman abilities after being bitten by a radioactive spider, becoming Spider-Man. Peter Parker is a fictional character portrayed by Tom Holland in the Marvel Cinematic Universe (MCU) media franchise–based on the Marvel Comics character of the same name-also known by his alias, Spider-Man. Superhuman strength, speed, reflexes, agility, coordination and balance.

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